5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione N-Oxide
Pioglitazone Hydrochloride
CAS: 112529-15-4;145350-09-0
Molecular Formula: C19H21ClN2O3S
5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione N-Oxide - Names and Identifiers
5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione N-Oxide - Physico-chemical Properties
| Molecular Formula | C19H21ClN2O3S |
| Molar Mass | 392.9 |
| Density | 1.329g/cm3 |
| Melting Point | 193-194°C |
| Boling Point | 666.324°C at 760 mmHg |
| Flash Point | 356.78°C |
| Water Solubility | Soluble in water (<1 mg/ml at 25°C), DMF, methanol, ethanol (4 mg/ml at 25°C), and DMSO (79 mg/ml at 25°C). |
| Solubility | DMSO : 100 mg/mL (254.52 mM; Need ultrasonic) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White to off-white (Solid) |
| Color | white to off-white |
| Merck | 14,7452 |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Refractive Index | 1.64 |
| MDL | MFCD04975446 |
| Physical and Chemical Properties | The appearance is white crystal powder, and the melting range is 193-194 ℃. |
| Use | A new generation of drugs for the treatment of type 2 diabetes |
5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione N-Oxide - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/38 - Irritating to eyes and skin. R36 - Irritating to the eyes |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | XJ5813440 |
| HS Code | 29341000 |
| Hazard Class | IRRITANT |
5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione N-Oxide - Reference
| Reference Show more | 1. [IF=5.81] Yin Jing et al."Danggui-Shaoyao-San Improves Gut Microbia Dysbiosis and Hepatic Lipid Homeostasis in Fructose-Fed Rats."Front Pharmacol. 2021 Jul;0:1752 |
5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione N-Oxide - Nature
Open Data Verified Data
colorless prismatic crystals were obtained from ethanol with a melting point of 193-194 °c.
Last Update：2024-01-02 23:10:35
5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione N-Oxide - Preparation Method
Open Data Verified Data
- (5-ethyl-2-pyridyl) ethanol is condensed with p-fluoronitrobenzene, and the resulting compound is then reduced to an amine and then diazotized in acetone-methanol containing hydrobromic acid, methyl acrylate was further added for coupling, followed by condensation and cyclization with thiourea, and then hydrolysis to give pioglitazone.
Last Update：2022-01-01 09:24:02
5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione N-Oxide - Use
Open Data Verified Data
research and development of the pharmaceutical industry in Koita, Japan. Approved by the U. S. Food and Drug Administration in 1999. Insulin sensitizer, for a new generation of Type II diabetes treatment drugs, side effects. It reduces insulin resistance in peripheral tissues and liver, increases insulin-dependent glucose processing, and reduces hepatic glucose output. Pioglitazone improves insulin sensitivity in patients with insulin resistance, increases insulin responsiveness to cells, and improves glucose homeostasis disorders. For the treatment of diabetes.
Last Update：2022-01-01 09:24:03
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Product Name: Pioglitazone Impurity 20 Visit Supplier Webpage Request for quotationCAS: 145350-09-0
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Product Name: Pioglitazone Hydrochloride Visit Supplier Webpage Request for quotationCAS: 112529-15-4
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Spot supply
Product Name: Pioglitazone Impurity 20 Visit Supplier Webpage Request for quotationCAS: 145350-09-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Pioglitazone Hydrochloride Visit Supplier Webpage Request for quotationCAS: 112529-15-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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